So I somewhat like trains, but I'm having a hard time finding games that are related to trains (please don't say Train Simulator 20XX :P) so I wonder if any of you have a train game to suggest?

It can be simulators, it can be turn based games, it can be sandboxes, it can be RPGs, it can be FPS, it can be anything as long as there are trains involved somehow.

Games suggested so far:
(The) 11th Hour - "Has a puzzle involving model train switching"
A-Train - "Simcity'ish games focusing more for transportation"
Agatha Christie: Murder on the Orient Express - "Takes place ofcourse on the Orient Express"
Arcanum: Of Steamworks and Magick Obscura - "Has a train running between towns"
Battle Isle - "Historyline 1914-18: the train gun is the strongest artillery unit in the game and the armored train isn't bad either"
Blood - "Has a level on a train"
Blood 2 - Train Level
BVE Trainsim - Train Simulator
Chris Sawyer's Locomotion - Train Business Simulator
Cities in Motion - Train Business Simulator (okay not really but still)
Command & Conquer: Tiberian Sun - Has trains according to tinyE
Commandos 3 - Train Level
Covert Ops: Nuclear Dawn - "The player controls Lieutenant Jack Morton of NATO, the sole survivor of a terrorist strike on the Blue Harvest, an armored train"
Densha de Go! - "Japanese train/tram -driving simulation with real routes"
DOOM - Train Level
Fear Equation - "You are The Engineer and you're in control of a very special train"
Final Fantasy VII - "The eco terrorists use trains to get between upper and lower Midgar, in connection to this there is a train graveyard. There is also an instance in the game in which our heroes must stop a train before it causes a catastrophe"
Final Fantasy VIII - "Aside from being able to take trains between continents–a service that the heroes use early on in the game–there is also a fairly advanced kidnapping mission involving two trains"
From Russia With Love - "Also has trains"
GoldenEye - Train level
Grand Theft Auto: San Andreas - "All you had to do was follow the train, CJ! There are two different trains you can ride, one is a slower train made for freight, the other is a faster passenger train. There is also a trolley, which is train-esque, however you can't ride it"
[/i]!"
Grand Theft Auto III - "Has a Subway and a heavy rail system. You can ride both"
Grand Theft Auto V - "While you can't seem to stop it, there is a scene where you have to drive a motorbike atop one and if you find the rights spots, you can jump onto the train and even make your way up to the engine and ride around enjoying the scenery"
GUN - "Has a train that you sabotage for a mission and another mission has you riding a rail. There is also a train owned by the game's big bad, it primarily only appears in cutscenes"
Half-Life - Train Level
Heart of China - "Has a nice train episode including a fencing duel on the roof of a moving train"
Hidden & Dangerous - "Has a level with a train"
IL2 Sturmovik: 1946 - "You can bomb/strafe trains"
(The) Last Express - "Takes place on a train."
(The) Legend of Zelda: Spirit Tracks - "That game revolves around operating a train"
Lego Loco - "It is a simple open-ended construction game with an emphasis on Rail Transport."
Locomancer - "A free model train simulator for VR. Bloody awesome fun, you can set up your model trains and even ride them"
Mace Griffin: Bountyhunter - Train Level (Minecarts)
Mass Effect - Train Level
Medal of Honor - "You run around a train station and blow up an armored train"
Medal of Honor: Frontline - "Has a level set on a moving train"
Metro: Last Light - Train Level
Metro 2033 - Train Level
Microsoft Train Simulator - Train Simulator
OpenTTD (Transport Tycoon Deluxe) - Train Business Simulator
(The) Operator: No One Lives Forever - Train Level
Outlaws - "One level is entirely on a moving train"
Rails Across America - Train Business Simulator
Railfan: Chicago Transit Authority Brown Line - Train Simulator
Railfan: Taiwan High Speed Rail - Train Simulator
Railroad Tycoon - Train Business Simulator
Railroad Tycoon 2 - Train Business Simulator
Railroad Tycoon 3 - Train Business Simulator
Red Faction - Train Level
Sid Meier's Railroads! - Train Business Simulator
SimSig - Train Simulator
Simutrans - Train Business Simulator
Sin - Train Level
Shogo: Mobile Armor Division - Train Level
Soldiers of Fortune - "Has at least 2 levels: 1 subway and 1 regular"
STALKER: Call of Pripyat - "There are trains"
Star Wars: Jedi Knight - Jedi Academy - Train Level
Syberia - Whole game is a train ride basically
Syberia 2 - See above game
Tom Clancy's Rainbow Six Vegas - "Has a trainyard level"
Tom Clancy's Splinter Cell: Pandora Tomorrow - Train Level
Tomb Raider: The Last Revelation - Train Level (GREAT according to tinyE)
(The) Train – Escape to Normandy - "The game starts with the capture of the train"
Train Fever - Train Business Simulator
Train Simulator - Train Simulator (no shit!)
Trainz - Train Simulator
Transarctica - "Mankind ekes out a living in a few handfuls of settlements, connected by a network of massive armored trains"
Underrail - "While not a bunch of trains, it is a huge expanse of, go figure, underground rail systems that make for a great setting for the game"
Vampire: The Masquerade - Bloodlines - "There's a trainyard in the warehouse level"
Wolfenstein: The New Order - "You spend five seconds on a train"
World of Subways - Train Simulator

You can bomb/strafe trains in IL-2 Sturmovik 1946.

you run around a train station and blow up a armored train in the original ps1 medal of honor

and there is a level on a train in goldeneye
and from russia with love also has trains

The Last Express takes place on a train. I don't know if it is fun, I never played it, I hear there are repetition parts that make the game less fun than it could be.

I looove the original Railroad Tycoon.

As it is being shown in people's posts already, there are definitely a lot of games that have train sequences/sections to them, and I could list a bunch I suppose (I love the location Rail Nomads in Wasteland 2 - it is an old train-yard with a series of quests and a quest series related to the people there and the story of what happened with the trains/train yard) but I don't know many that it is a main focal point for the entire game.

You can't go wrong with OpenTTD. It's free too.

Well there's the Railroad Tycoon series, Train Fever.. Blood has a level on a train.
You spend five seconds on a train in Wolfenstein: The New Order.
Hidden & Dangerous had a level with a train, the first one I think.
And that's all I can think of right now.
There might be some games where you're running a train.. but that's not really my kind of genre.

Edit: Just thought of two more: Transarctica by Silmarillion and the PSX game Covert Ops.

Medal of Honor: Frontline has a level set on a moving train.

In GTA San Andreas all you had to do was follow the train, CJ!

Yeah, while dodging other trains, cars, trucks, and jumping off cliffs! :P

totally forgot about the last express
murder on the orient express takes place off course on the orient express

First person shooters I remember with trainlevels:

- Shogo
- Blood 1+2
- No One Lives Forever
- Red Faction
- Sin
- Half-Life
- Mace Griffin: Bounty Hunter (minecarts, don't know if that counts)
- Metro 2033 and Last Light
- Splinter Cell: Pandorra Tomorrow (third person)

there's a train on that wintery research station level in Mass Effect (the station where you fight Benezia)

there's a train in DOOM2016 at one point

LEGO Loco

Arcanum has a train running between towns I think.

TR IV has a GREAT train level. Best level in the game.